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By far, the most common symptoms are complaints: feeling tired, "brain fog" (short-term memory problems and difficulty concentrating) and muscle pain. These complaints are common to a large number of medical conditions, from psychiatric conditions such as major depressive disorder to neurological conditions such as orthostatic intolerance to high blood pressure, autoimmune diseases and cancer.

A partial list of other symptoms patients have attributed to MCS include difficulty breathing, pains in the throat, chest, or abdominal region, asthma, skin irritation, contact dermatitis, and hives or other forms of skin rash, headaches, neurological symptoms (nerve pain, pins and needles feelings, weakness, trembling, restless leg syndrome, etc.), tendonitis, seizures, visual disturbances (blurring, halo effect, inability to focus), extreme anxiety, panic and/or anger, sleep disturbance, suppression of immune system, digestive difficulties, nausea, indigestion/heartburn, vomiting, diarrhea, joint pains, vertigo/dizziness, abnormally acute sense of smell, sensitivity to natural plant fragrance or natural pine terpenes, insomnia, dry mouth, dry eyes, and an overactive bladder.